About Fosaprepitant API
Therapeutic CategoryOncology/Anti-Emetics
CAS Number
265121-04-8
API Technology
Synthetic
Dose Form
Injectable
Dr Reddy's Development Status
Available
Available Regulatory Filing
USDMF, Brazil DMF
Mechanism of Action
Fosaprepitant is a prodrug of aprepitant and accordingly, its antiemetic effects are attributable to aprepitant. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CINV). Aprepitant has been shown in animal models to inhibit emesis induced by cytotoxic chemotherapeutic agents, such as cisplatin, via central actions. Animal and human Positron Emission Tomography (PET) studies with aprepitant have shown that it crosses the blood brain barrier and occupies brain NK1 receptors. Animal and human studies have shown that aprepitant augments the antiemetic activity of the 5-HT3-receptor antagonist ondansetron and the corticosteroid dexamethasone and inhibits both the acute and delayed phases of cisplatin-induced emesis.
Indication
EMEND for injection is a substance P/neurokinin-1 (NK1) receptor antagonist, indicated in adults and pediatric patients 6 months of age and older, in combination with other antiemetic agents, for the prevention of (1):
- Acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy (HEC) including high-dose cisplatin.
- Delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy (MEC)
Related APIs
Ondansetrón
Oncology/Anti-Emetics
Ondansetrón Clorhidrato
Oncology/Anti-Emetics
Palonosetrón Clorhidrato
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Fosaprepitante
Oncology/Anti-Emetics
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Related Resources
Dr. Reddy’s Fosaprepitant API offerings
Fosaprepitant is indicated for preventing acute and delayed nausea and vomiting associated with moderately or highly emetogenic chemotherapy combined with other antiemetic agents. The US FDA and EMA approved fosaprepitant in 2008, and the PMDA in 2011. As of December 2020, this corresponds to an API demand of 500 kg per year (IQVIA MAT).
We offer stable amorphous API which meets global regulatory requirements and formulation needs of customers. To know more about Dr. Reddy’s Fosaprepitant offerings Read the technical sheet on this topic by filling the contact form below.
FAQs
Prevents acute and delayed nausea and vomiting associated with chemotherapy
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Available as intravenous injection: 150 mg/vial.
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Reduces chemotherapy-induced nausea and vomiting
Enhances patient comfort during cancer treatment
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Store intact vials at 2°C to 8°C (36°F to 46°F)
Reconstituted solution stable for 24 hours at room temperature (≤25°C/77°F)
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