About Posaconazole API
Therapeutic CategoryAnti-Infective
CAS Number
171228-49-2
API Technology
Synthetic
Dose Form
Suspension, Tablets, Delayed released tablets and solution
Dr Reddy's Development Status
Available
Available Regulatory Filing
USDMF
Mechanism of Action
Posaconazole blocks the synthesis of ergosterol, a key component of the fungal cell membrane, through the inhibition of cytochrome P-450 dependent enzyme lanosterol 14α-demethylase responsible for the conversion of lanosterol to ergosterol in the fungal cell membrane. This results in an accumulation of methylated sterol precursors and a depletion of ergosterol within the cell membrane thus weakening the structure and function of the fungal cell membrane. This may be responsible for the antifungal activity of posaconazole.
Indication
Noxafil is an azole antifungal agent indicated for: injection, delayed-release tablets, and oral suspension
- Prophylaxis of invasive Aspergillus and Candida infections in patients who are at high risk of developing these infections due to being severely immunocompromised, such as HSCT recipients with GVHD or those with hematologic malignancies with prolonged neutropenia from chemotherapy. Oral suspension
- Treatment of oropharyngeal candidiasis (OPC), including OPC refractory (rOPC) to itraconazole and/or fluconazole.
Related APIs
Ciprofloxacin Hydrochloride
Anti-Infective
Gatifloxacin (Anhydrous)
Anti-Infective
Levofloxacin Hemihydrate
Anti-Infective
Moxifloxacin Hydrochloride (Anhydrous)
Anti-Infective
Permethrin
Anti-Infective
Posaconazole
Anti-Infective
Terbinafine Hydrochloride
Anti-Infective
Request for Quotation
Get in touch with us by filling out the form below. Our team will reach out to you shortly!
Disclaimer
No information on this website, including any reference to any product or service constitutes an offer for sale or be construed as representing an offer for sale. Products protected under valid patents are not offered or supplied for commercial use. However, in certain cases, at Dr. Reddy's sole discretion, and subject to local legal requirement, the research quantities of such products may be offered for the purpose of regulatory submissions under Section 107A of the Indian Patent Act (Bolar exemption), wherever such regulatory exemptions exist. The buyers should make their independent evaluation of the product or service including, patent scenario in their respective markets and will be responsible for all patent related liabilities Dr. Reddy's disclaims all warranties, express or implied, including but not limited to warranties of merchantability, fitness for a particular purpose and non-infringement.